Categoria
Valdecoxib [USAN]
Nombres de marca,
Valdecoxib [USAN]
Analogos
Valdecoxib [USAN]
Marca los nombres de mezcla
No information avaliable
Valdecoxib [USAN]
Formula quimica
C16H14N2O3S
Valdecoxib [USAN]
RX enlace
http://www.rxlist.com/cgi/generic/bextra.htm
Valdecoxib [USAN]
FDA hoja
Valdecoxib [USAN]
MSDS (hoja de seguridad de materiales)
Valdecoxib [USAN]
Sintesis de referencia
No hay información disponible
Valdecoxib [USAN]
Peso molecular
314.36 g/mol
Valdecoxib [USAN]
Punto de fusion
No information avaliable
Valdecoxib [USAN]
H2O Solubilidad
No hay información disponible
Valdecoxib [USAN]
Estado
Solid
Valdecoxib [USAN]
LogP
3.003
Valdecoxib [USAN]
Formas de dosificacion
Tableta
Valdecoxib [USAN]
Indicacion
Para el tratamiento de la artrosis y dismenorrea
Valdecoxib [USAN]
Farmacologia
Valdecoxib, un ciclooxigenasa-2 (COX-2) inhibidores, se clasifica como antiinflamatorios no esteroideos (AINE). Valdecoxib se utiliza para sus actividades anti-inflamatorias, analgésicas y antipiréticas en el manejo de la osteoartritis (OA) y para el tratamiento de la dismenorrea o dolor agudo. A diferencia de celecoxib, valdecoxib carece de una cadena sulfonamida y no requiere de enzimas del citocromo P450 para el metabolismo.
Valdecoxib [USAN]
Absorcion
No hay información disponible
Valdecoxib [USAN]
Toxicidad
No hay información disponible
Valdecoxib [USAN]
Informacion de Pacientes
BEXTRA can cause GI discomfort and, rarely, more serious GI side effects, which may result in
hospitalization and even fatal outcomes. Although serious GI tract ulcerations and bleeding can occur without warning
symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical
advice when observing any indicative sign or symptoms. Patients should be apprised of the importance of this
follow-up Effects ó Risk of GI Ulceration, Bleeding, and Perforation).
Patients should report to their physicians, signs or symptoms of gastrointestinal ulceration or
bleeding, skin rash, weight gain, or edema.
Patients should be informed of the warning signs and symptoms of hepatotoxicity (e.g., nausea,
fatigue, lethargy, pruritus, jaundice, right upper quadrant tenderness, and flu-like symptoms). If these occur,
patients should be instructed to stop therapy and seek immediate medical attention.
Patients should also be instructed to seek immediate emergency help in the case of an anaphylactoid
reaction.
In late pregnancy, BEXTRA should be avoided because it may cause premature closure of the ductus
arteriosus.
Valdecoxib [USAN]
Organismos afectados
Humanos y otros mamíferos